ParkinsonCanadaV1, Main, Exploration, bibRecord, 001640

Lrrk2 p.Q1111H substitution and Parkinson’s disease in Latin America

Identifieur interne : 001640 ( Main/Exploration ); précédent : 001639; suivant : 001641

Lrrk2 p.Q1111H substitution and Parkinson’s disease in Latin America

Auteurs : Ignacio F. Mata [États-Unis] ; Greggory J. Wilhoite [États-Unis] ; Dora Yearout [États-Unis] ; Justin A. Bacon [États-Unis] ; Mario Cornejo [Pérou] ; Pilar Mazzetti [Pérou] ; Victoria Marca [Pérou] ; Olimpio Ortega [Pérou] ; Oscar Acosta [Pérou] ; Carlos Cosentino [Pérou] ; Luis Torres [Pérou] ; Angel C. Medina [Pérou] ; Carolina Perez-Pastene [Chili] ; Fernando Díaz-Grez [Chili] ; Carles Vilari O-Güell [États-Unis, Canada] ; Pablo Venegas ; Marcelo Miranda [Chili] ; Osvaldo Trujillo-Godoy ; Luis Layson [Chili] ; Rodrigo Avello [Chili] ; Elena Dieguez [Uruguay] ; Victor Raggio [Uruguay] ; Federico Micheli [Argentine] ; Claudia Perandones [Argentine] ; Victoria Alvarez [Espagne] ; Juan Segura-Aguilar [Pérou] ; Matthew J. Farrer [États-Unis, Canada] ; Cyrus P. Zabetian [États-Unis] ; Owen A. Ross [États-Unis]

Source :

Parkinsonism & related disorders [ 1353-8020 ] ; 2011.

RBID : PMC:3167927

Abstract

Mutations in the LRRK2 gene are the most common genetic cause of Parkinson’s disease, with frequencies displaying a high degree of population-specificity. Although more than 100 coding substitutions have been identified, only seven have been proven to be highly penetrant pathogenic mutations. Studies however are lacking in non-white populations. Recently, Lrrk2 p.Q1111H (rs78365431) was identified in two affected Hispanic brothers and absent in 386 non-Hispanic white healthy controls. We therefore screened this variant in 1460 individuals (1150 PD patients and 310 healthy controls) from 4 Latin American countries (Peru, Chile, Uruguay and Argentina).

In our case-control series from Peru and Chile we observed an increased frequency of Lrrk2 p.Q1111H in patients (7.9%) compared to controls (5.4%) although the difference did not reach significance (OR 1.38; p=0.10).

In addition, the frequency of Lrrk2 p.Q1111H varied greatly between populations and further screening in a set of pure Amerindian and pure Spanish controls suggested that this variant likely originated in an Amerindian population. Further studies in other Latin American populations are warranted to assess its role as a risk factor for Parkinson’s disease. Screening in Parkinson’s disease patients from under-represented populations will increase our understanding of the role of LRRK2 variants in disease risk worldwide.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167927

DOI: 10.1016/j.parkreldis.2011.05.003
PubMed: 21632271
PubMed Central: 3167927

Affiliations:

Argentine, Canada, Chili, Espagne, Pérou, Uruguay, États-Unis
Floride, Washington (État)

Le document en format XML

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<author><name sortKey="Acosta, Oscar" sort="Acosta, Oscar" uniqKey="Acosta O" first="Oscar" last="Acosta">Oscar Acosta</name>
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<author><name sortKey="Venegas, Pablo" sort="Venegas, Pablo" uniqKey="Venegas P" first="Pablo" last="Venegas">Pablo Venegas</name>
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<author><name sortKey="Miranda, Marcelo" sort="Miranda, Marcelo" uniqKey="Miranda M" first="Marcelo" last="Miranda">Marcelo Miranda</name>
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<author><name sortKey="Trujillo Godoy, Osvaldo" sort="Trujillo Godoy, Osvaldo" uniqKey="Trujillo Godoy O" first="Osvaldo" last="Trujillo-Godoy">Osvaldo Trujillo-Godoy</name>
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<author><name sortKey="Raggio, Victor" sort="Raggio, Victor" uniqKey="Raggio V" first="Victor" last="Raggio">Victor Raggio</name>
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<author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name>
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<author><name sortKey="Segura Aguilar, Juan" sort="Segura Aguilar, Juan" uniqKey="Segura Aguilar J" first="Juan" last="Segura-Aguilar">Juan Segura-Aguilar</name>
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<author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
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<author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
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<author><name sortKey="Bacon, Justin A" sort="Bacon, Justin A" uniqKey="Bacon J" first="Justin A." last="Bacon">Justin A. Bacon</name>
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</affiliation>
</author>
<author><name sortKey="Mazzetti, Pilar" sort="Mazzetti, Pilar" uniqKey="Mazzetti P" first="Pilar" last="Mazzetti">Pilar Mazzetti</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Neurogenetics Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru</nlm:aff>
<country xml:lang="fr">Pérou</country>
<wicri:regionArea>Neurogenetics Unit, Instituto Nacional de Ciencias Neurologicas, Lima</wicri:regionArea>
<wicri:noRegion>Lima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marca, Victoria" sort="Marca, Victoria" uniqKey="Marca V" first="Victoria" last="Marca">Victoria Marca</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Neurogenetics Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru</nlm:aff>
<country xml:lang="fr">Pérou</country>
<wicri:regionArea>Neurogenetics Unit, Instituto Nacional de Ciencias Neurologicas, Lima</wicri:regionArea>
<wicri:noRegion>Lima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ortega, Olimpio" sort="Ortega, Olimpio" uniqKey="Ortega O" first="Olimpio" last="Ortega">Olimpio Ortega</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Neurogenetics Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru</nlm:aff>
<country xml:lang="fr">Pérou</country>
<wicri:regionArea>Neurogenetics Unit, Instituto Nacional de Ciencias Neurologicas, Lima</wicri:regionArea>
<wicri:noRegion>Lima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Acosta, Oscar" sort="Acosta, Oscar" uniqKey="Acosta O" first="Oscar" last="Acosta">Oscar Acosta</name>
<affiliation wicri:level="1"><nlm:aff id="A5">School of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru</nlm:aff>
<country xml:lang="fr">Pérou</country>
<wicri:regionArea>School of Medicine, Universidad Nacional Mayor de San Marcos, Lima</wicri:regionArea>
<wicri:noRegion>Lima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cosentino, Carlos" sort="Cosentino, Carlos" uniqKey="Cosentino C" first="Carlos" last="Cosentino">Carlos Cosentino</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Movement disorders, Instituto Nacional de Ciencias Neurologicas, Lima, Peru</nlm:aff>
<country xml:lang="fr">Pérou</country>
<wicri:regionArea>Movement disorders, Instituto Nacional de Ciencias Neurologicas, Lima</wicri:regionArea>
<wicri:noRegion>Lima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Torres, Luis" sort="Torres, Luis" uniqKey="Torres L" first="Luis" last="Torres">Luis Torres</name>
<affiliation wicri:level="1"><nlm:aff id="A6">Movement disorders, Instituto Nacional de Ciencias Neurologicas, Lima, Peru</nlm:aff>
<country xml:lang="fr">Pérou</country>
<wicri:regionArea>Movement disorders, Instituto Nacional de Ciencias Neurologicas, Lima</wicri:regionArea>
<wicri:noRegion>Lima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Medina, Angel C" sort="Medina, Angel C" uniqKey="Medina A" first="Angel C." last="Medina">Angel C. Medina</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Universidad Nacional del Altiplano, Puno, Peru</nlm:aff>
<country xml:lang="fr">Pérou</country>
<wicri:regionArea>Universidad Nacional del Altiplano, Puno</wicri:regionArea>
<wicri:noRegion>Puno</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perez Pastene, Carolina" sort="Perez Pastene, Carolina" uniqKey="Perez Pastene C" first="Carolina" last="Perez-Pastene">Carolina Perez-Pastene</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile</nlm:aff>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago</wicri:regionArea>
<wicri:noRegion>Santiago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Diaz Grez, Fernando" sort="Diaz Grez, Fernando" uniqKey="Diaz Grez F" first="Fernando" last="Díaz-Grez">Fernando Díaz-Grez</name>
<affiliation wicri:level="1"><nlm:aff id="A8">Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile</nlm:aff>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Santiago</wicri:regionArea>
<wicri:noRegion>Santiago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Venegas, Pablo" sort="Venegas, Pablo" uniqKey="Venegas P" first="Pablo" last="Venegas">Pablo Venegas</name>
<affiliation><nlm:aff id="A10">Liga del Parkinson de Chile</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Miranda, Marcelo" sort="Miranda, Marcelo" uniqKey="Miranda M" first="Marcelo" last="Miranda">Marcelo Miranda</name>
<affiliation><nlm:aff id="A10">Liga del Parkinson de Chile</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11">Clinica Las Condes, Santiago, Chile</nlm:aff>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Clinica Las Condes, Santiago</wicri:regionArea>
<wicri:noRegion>Santiago</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trujillo Godoy, Osvaldo" sort="Trujillo Godoy, Osvaldo" uniqKey="Trujillo Godoy O" first="Osvaldo" last="Trujillo-Godoy">Osvaldo Trujillo-Godoy</name>
<affiliation><nlm:aff id="A10">Liga del Parkinson de Chile</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Layson, Luis" sort="Layson, Luis" uniqKey="Layson L" first="Luis" last="Layson">Luis Layson</name>
<affiliation wicri:level="1"><nlm:aff id="A12">Hospital Barros Luco Trudeau, Chile</nlm:aff>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Hospital Barros Luco Trudeau</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Avello, Rodrigo" sort="Avello, Rodrigo" uniqKey="Avello R" first="Rodrigo" last="Avello">Rodrigo Avello</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Hospital Regional de Concepcion, Chile</nlm:aff>
<country xml:lang="fr">Chili</country>
<wicri:regionArea>Hospital Regional de Concepcion</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dieguez, Elena" sort="Dieguez, Elena" uniqKey="Dieguez E" first="Elena" last="Dieguez">Elena Dieguez</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Department of Neurology, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>Department of Neurology, Facultad de Medicina, Universidad de la Republica, Montevideo</wicri:regionArea>
<wicri:noRegion>Montevideo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Raggio, Victor" sort="Raggio, Victor" uniqKey="Raggio V" first="Victor" last="Raggio">Victor Raggio</name>
<affiliation wicri:level="1"><nlm:aff id="A15">Department of Genetics, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay</nlm:aff>
<country xml:lang="fr">Uruguay</country>
<wicri:regionArea>Department of Genetics, Facultad de Medicina, Universidad de la Republica, Montevideo</wicri:regionArea>
<wicri:noRegion>Montevideo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Micheli, Federico" sort="Micheli, Federico" uniqKey="Micheli F" first="Federico" last="Micheli">Federico Micheli</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Department of Neurology, Hospital de Clinicas, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Department of Neurology, Hospital de Clinicas, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Perandones, Claudia" sort="Perandones, Claudia" uniqKey="Perandones C" first="Claudia" last="Perandones">Claudia Perandones</name>
<affiliation wicri:level="1"><nlm:aff id="A16">Department of Neurology, Hospital de Clinicas, Buenos Aires, Argentina</nlm:aff>
<country xml:lang="fr">Argentine</country>
<wicri:regionArea>Department of Neurology, Hospital de Clinicas, Buenos Aires</wicri:regionArea>
<wicri:noRegion>Buenos Aires</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Laboratorio de Genetica Molecular, Instituto de Investigacion Nefrologica (IRSINFRIAT), Hospital Universitario Central de Asturias, Oviedo, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Laboratorio de Genetica Molecular, Instituto de Investigacion Nefrologica (IRSINFRIAT), Hospital Universitario Central de Asturias, Oviedo</wicri:regionArea>
<wicri:noRegion>Oviedo</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Segura Aguilar, Juan" sort="Segura Aguilar, Juan" uniqKey="Segura Aguilar J" first="Juan" last="Segura-Aguilar">Juan Segura-Aguilar</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Neurogenetics Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Peru</nlm:aff>
<country xml:lang="fr">Pérou</country>
<wicri:regionArea>Neurogenetics Unit, Instituto Nacional de Ciencias Neurologicas, Lima</wicri:regionArea>
<wicri:noRegion>Lima</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A9">Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Canada</country>
<wicri:regionArea>Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Veterans Affairs Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Washington School of Medicine, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A3">Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Parkinsonism & related disorders</title>
<idno type="ISSN">1353-8020</idno>
<idno type="eISSN">1873-5126</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Mutations in the <italic>LRRK2</italic>
 gene are the most common genetic cause of Parkinson’s disease, with frequencies displaying a high degree of population-specificity. Although more than 100 coding substitutions have been identified, only seven have been proven to be highly penetrant pathogenic mutations. Studies however are lacking in non-white populations. Recently, Lrrk2 p.Q1111H (rs78365431) was identified in two affected Hispanic brothers and absent in 386 non-Hispanic white healthy controls. We therefore screened this variant in 1460 individuals (1150 PD patients and 310 healthy controls) from 4 Latin American countries (Peru, Chile, Uruguay and Argentina).</p>
<p id="P2">In our case-control series from Peru and Chile we observed an increased frequency of Lrrk2 p.Q1111H in patients (7.9%) compared to controls (5.4%) although the difference did not reach significance (OR 1.38; <italic>p</italic>
=0.10).</p>
<p id="P3">In addition, the frequency of Lrrk2 p.Q1111H varied greatly between populations and further screening in a set of pure Amerindian and pure Spanish controls suggested that this variant likely originated in an Amerindian population. Further studies in other Latin American populations are warranted to assess its role as a risk factor for Parkinson’s disease. Screening in Parkinson’s disease patients from under-represented populations will increase our understanding of the role of <italic>LRRK2</italic>
 variants in disease risk worldwide.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Argentine</li>
<li>Canada</li>
<li>Chili</li>
<li>Espagne</li>
<li>Pérou</li>
<li>Uruguay</li>
<li>États-Unis</li>
</country>
<region><li>Floride</li>
<li>Washington (État)</li>
</region>
</list>
<tree><noCountry><name sortKey="Trujillo Godoy, Osvaldo" sort="Trujillo Godoy, Osvaldo" uniqKey="Trujillo Godoy O" first="Osvaldo" last="Trujillo-Godoy">Osvaldo Trujillo-Godoy</name>
<name sortKey="Venegas, Pablo" sort="Venegas, Pablo" uniqKey="Venegas P" first="Pablo" last="Venegas">Pablo Venegas</name>
</noCountry>
<country name="États-Unis"><noRegion><name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F." last="Mata">Ignacio F. Mata</name>
</noRegion>
<name sortKey="Bacon, Justin A" sort="Bacon, Justin A" uniqKey="Bacon J" first="Justin A." last="Bacon">Justin A. Bacon</name>
<name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
<name sortKey="Mata, Ignacio F" sort="Mata, Ignacio F" uniqKey="Mata I" first="Ignacio F." last="Mata">Ignacio F. Mata</name>
<name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name>
<name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name>
<name sortKey="Wilhoite, Greggory J" sort="Wilhoite, Greggory J" uniqKey="Wilhoite G" first="Greggory J." last="Wilhoite">Greggory J. Wilhoite</name>
<name sortKey="Yearout, Dora" sort="Yearout, Dora" uniqKey="Yearout D" first="Dora" last="Yearout">Dora Yearout</name>
<name sortKey="Yearout, Dora" sort="Yearout, Dora" uniqKey="Yearout D" first="Dora" last="Yearout">Dora Yearout</name>
<name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
<name sortKey="Zabetian, Cyrus P" sort="Zabetian, Cyrus P" uniqKey="Zabetian C" first="Cyrus P." last="Zabetian">Cyrus P. Zabetian</name>
</country>
<country name="Pérou"><noRegion><name sortKey="Cornejo, Mario" sort="Cornejo, Mario" uniqKey="Cornejo M" first="Mario" last="Cornejo">Mario Cornejo</name>
</noRegion>
<name sortKey="Acosta, Oscar" sort="Acosta, Oscar" uniqKey="Acosta O" first="Oscar" last="Acosta">Oscar Acosta</name>
<name sortKey="Cosentino, Carlos" sort="Cosentino, Carlos" uniqKey="Cosentino C" first="Carlos" last="Cosentino">Carlos Cosentino</name>
<name sortKey="Marca, Victoria" sort="Marca, Victoria" uniqKey="Marca V" first="Victoria" last="Marca">Victoria Marca</name>
<name sortKey="Mazzetti, Pilar" sort="Mazzetti, Pilar" uniqKey="Mazzetti P" first="Pilar" last="Mazzetti">Pilar Mazzetti</name>
<name sortKey="Medina, Angel C" sort="Medina, Angel C" uniqKey="Medina A" first="Angel C." last="Medina">Angel C. Medina</name>
<name sortKey="Ortega, Olimpio" sort="Ortega, Olimpio" uniqKey="Ortega O" first="Olimpio" last="Ortega">Olimpio Ortega</name>
<name sortKey="Segura Aguilar, Juan" sort="Segura Aguilar, Juan" uniqKey="Segura Aguilar J" first="Juan" last="Segura-Aguilar">Juan Segura-Aguilar</name>
<name sortKey="Torres, Luis" sort="Torres, Luis" uniqKey="Torres L" first="Luis" last="Torres">Luis Torres</name>
</country>
<country name="Chili"><noRegion><name sortKey="Perez Pastene, Carolina" sort="Perez Pastene, Carolina" uniqKey="Perez Pastene C" first="Carolina" last="Perez-Pastene">Carolina Perez-Pastene</name>
</noRegion>
<name sortKey="Avello, Rodrigo" sort="Avello, Rodrigo" uniqKey="Avello R" first="Rodrigo" last="Avello">Rodrigo Avello</name>
<name sortKey="Diaz Grez, Fernando" sort="Diaz Grez, Fernando" uniqKey="Diaz Grez F" first="Fernando" last="Díaz-Grez">Fernando Díaz-Grez</name>
<name sortKey="Layson, Luis" sort="Layson, Luis" uniqKey="Layson L" first="Luis" last="Layson">Luis Layson</name>
<name sortKey="Miranda, Marcelo" sort="Miranda, Marcelo" uniqKey="Miranda M" first="Marcelo" last="Miranda">Marcelo Miranda</name>
</country>
<country name="Canada"><noRegion><name sortKey="Vilari O Guell, Carles" sort="Vilari O Guell, Carles" uniqKey="Vilari O Guell C" first="Carles" last="Vilari O-Güell">Carles Vilari O-Güell</name>
</noRegion>
<name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name>
</country>
<country name="Uruguay"><noRegion><name sortKey="Dieguez, Elena" sort="Dieguez, Elena" uniqKey="Dieguez E" first="Elena" last="Dieguez">Elena Dieguez</name>
</noRegion>
<name sortKey="Raggio, Victor" sort="Raggio, Victor" uniqKey="Raggio V" first="Victor" last="Raggio">Victor Raggio</name>
</country>
<country name="Argentine"><noRegion><name sortKey="Micheli, Federico" sort="Micheli, Federico" uniqKey="Micheli F" first="Federico" last="Micheli">Federico Micheli</name>
</noRegion>
<name sortKey="Perandones, Claudia" sort="Perandones, Claudia" uniqKey="Perandones C" first="Claudia" last="Perandones">Claudia Perandones</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Alvarez, Victoria" sort="Alvarez, Victoria" uniqKey="Alvarez V" first="Victoria" last="Alvarez">Victoria Alvarez</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

Lrrk2 p.Q1111H substitution and Parkinson’s disease in Latin America

Lrrk2 p.Q1111H substitution and Parkinson’s disease in Latin America

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	La maladie de Parkinson au Canada (serveur d'exploration)
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